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Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

《医学前沿（英文）》 2019年 第13卷 第6期   页码 705-712 doi: 10.1007/s11684-019-0703-y

摘要： Wnt and Notch signaling play crucial roles in the determination of the prosensory domain and in the differentiation of hair cells (HCs) and supporting cells during mouse inner ear development; however, the relationship between the two signaling pathways in the mouse cochlea remains largely unknown. Here, we investigated the interactions between Notch and Wnt signaling on the basis of the bidirectional regulation of Notch1 specifically in Wnt-responsive Lgr5 progenitors during different cochlear development stages. We found that the downregulation of Notch1 in Lgr5 cells from embryonic day (E) 14.5 to E18.5 can drive the quiescent Lgr5 cells to re-enter the cell cycle and differentiate into extra HCs, whereas the upregulation of Notch1 expression did not affect the proliferation or differentiation of otic progenitor cells. No effect was observed on the upregulation or downregulation of Notch1 in Lgr5 cells from E10.5 to E14.5. We concluded that the roles of Notch1 in Wnt-responsive Lgr5 cells are unidirectional and stage dependent and Notch1 serves as a negative regulator for Lgr5 progenitor activation during cochlear differentiation. Our findings improved the understanding of the interactions between Notch and Wnt signaling in cochlear development.

关键词： inner ear     cochlear     Wnt     Notch     Lgr5     auditory system    

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P50 auditory sensory gating in first onset schizophrenics and normal healthy adults

WANG Hongxing, ZHANG Mingdao, CHEN Xingshi, LOU Feiying, LIANG Jianhua, CHEN Chong, SHI Tiantao, LU Qiulin

《医学前沿（英文）》 2007年 第1卷 第4期   页码 429-432 doi: 10.1007/s11684-007-0084-5

摘要： The aim of this research was to investigate the variations of P50 auditory sensory gating (P50) in normal healthy adults and the first onset schizophrenics. By using the American Nicolet Bravo electromyography/evoked potential (EMG/EP) system, P50 was measured with conditioning-testing paradigm (paired-click stimuli S1 and S2 were used) in 58 first onset schizophrenics and 108 healthy adults, and the Positive and Negative Syndrome Scale (PANSS) was applied. The following three conclusions have been reached. (1) In normal control (NC) group, measured from central, anterior and posterior zone (Cz, Fz and Pz respectively), there were no statistical differences (>0.05) between S1 and S2 evoked P50 peak latencies (S1-P50 and S2-P50); the amplitudes of S2-P50 [(2.2±1.4), (2.3±1.5) and (2.1±1.4) μV respectively] reduced significantly as compared with S1-P50 [(5.6±3.3), (5.6±3.9) and (4.9±2.8) μV respectively] (<0.01); the S2/S1 ration, S1-S2 difference, and 100 (1-S2/S1) had no statistical differences (>0.05). (2) Compared with NC, the schizophrenic group significantly showed lower S1-P50 amplitudes (<0.01, except at Pz in which = 2.030, = 0.042), higher S2-P50 amplitudes, higher S2/S1 ratio, lower S1-S2 difference, and more decreased 100 (1-S2/S1) (<0.01) at Cz, Fz and Pz. (3) No significant correlations were found among S2/S1 ratio, S1-S2, 100 (1-S2/S1) of sensory gating and PANSS (>0.05) in schizophrenic group. The first onset schizophrenics had sensory gating deficits, which could be quantified by P50.

关键词： anterior     Positive     S2-P50     schizophrenic     EMG/EP    

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Behavioral methods for the functional assessment of hair cells in zebrafish

null

《医学前沿（英文）》 2017年 第11卷 第2期   页码 178-190 doi: 10.1007/s11684-017-0507-x

摘要：

Zebrafish is an emerging animal model for studies on auditory system. This model presents high comparability with humans, good accessibility to the hearing organ, and high throughput capacity. To better utilize this animal model, methodologies need to be used to quantify the hearing function of the zebrafish. Zebrafish displays a series of innate and robust behavior related to its auditory function. Here, we reviewed the advantage of using zebrafish in auditory research and then introduced three behavioral tests, as follows: the startle response, the vestibular-ocular reflex, and rheotaxis. These tests are discussed in terms of their physiological characteristics, up-to-date technical development, and apparatus description. Test limitation and areas to improve are also introduced. Finally, we revealed the feasibility of these applications in zebrafish behavioral assessment and their potential in the high-throughput screening on hearing-related genes and drugs.

关键词： zebrafish (Danio rerio)     behavior     auditory     startle response     vestibular-ocular reflex     rheotaxis    

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鸡尾酒会问题的技术回顾、当前进展及未来挑战 Review

Yan-min QIAN, Chao WENG, Xuan-kai CHANG, Shuai WANG, Dong YU

《信息与电子工程前沿（英文）》 2018年 第19卷 第1期   页码 40-63 doi: 10.1631/FITEE.1700814

摘要： 介绍了以下内容：传统的单通道情况下的技术，如计算听觉场景分析（computational auditory scene analysis, CASA）、非负矩阵分解（non-negative matrix

关键词： 鸡尾酒会问题；计算听觉场景分析；非负矩阵分解；排列不变性训练；多说话人语音处理    

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AI2.0时代的类人与超人感知：研究综述与趋势展望 Review

Yong-hong TIAN,Xi-lin CHEN,Hong-kai XIONG,Hong-liang LI,Li-rong DAI,Jing CHEN,Jun-liang XING,Jing CHEN,Xi-hong WU,Wei-min HU,Yu HU,Tie-jun HUANG,Wen GAO

《信息与电子工程前沿（英文）》 2017年 第18卷 第1期   页码 58-67 doi: 10.1631/FITEE.1601804

摘要： 感知是智能系统与现实世界的交互界面。如果没有复杂而灵活的感知能力，就不可能创造出高级的人工智能（AI）系统。最近，潘云鹤院士提出了AI 2.0的概念，其最重要的特征就是未来的AI系统应拥有类人甚至超人的智能感知能力。本文简要回顾了不同智能感知领域的研究现状，包括视觉感知、听觉感知、言语感知、感知信息处理与学习引擎等方面。在此基础上，论文对即将到来的AI 2.0时代智能感知领域需要大力研究发展的重点方向进行了展望，包括：（1）类人和超人的主动视觉；（2）自然声学场景的听知觉感知；（3）自然交互环境的言语感知及计算；（4）面向媒体感知的自主学习；（5）大规模感知信息处理与学习引擎；（6）城市全维度智能感知推理引擎。这些研究方向应在未来AI 2.0的研究规划中进行重点布局。

关键词： 智能感知；主动视觉；听觉感知；言语感知；自主学习    

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System reliability and system resilience

《工程管理前沿（英文）》 2021年 第8卷 第4期   页码 615-619 doi: 10.1007/s42524-021-0176-y

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工程 工程系统 工程系统论与工程科学体系

王连成

《中国工程科学》 2001年 第3卷 第6期   页码 15-18

摘要：

从分析工程的基本内容、性质和特征人手，引出了工程系统的概念，接着应用一般系统论思想讨论了工程系统论的研究对象和研究方法，并论述了它在整个工程科学体系中的元学科地位。

关键词： 工程     系统     系统论     学科    

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Cyber–Physical Power System (CPPS): A review on measures and optimization methods of system resilience

《工程管理前沿（英文）》 2021年 第8卷 第4期   页码 503-518 doi: 10.1007/s42524-021-0163-3

摘要： The Cyber–Physical Power System (CPPS) is one of the most critical infrastructure systems in a country because a stable and secure power supply is a key foundation for national and social development. In recent years, resilience has become a major topic in preventing and mitigating the risks caused by large-scale blackouts of CPPSs. Accordingly, the concept and significance of CPPS resilience are at first explained from the engineering perspective in this study. Then, a review of representative quantitative assessment measures of CPPS resilience applied in the existing literature is provided. On the basis of these assessment measures, the optimization methods of CPPS resilience are reviewed from three perspectives, which are mainly focused on the current research, namely, optimizing the recovery sequence of components, identifying and protecting critical nodes, and enhancing the coupling patterns between physical and cyber networks. The recent advances in modeling methods for cascading failures within the CPPS, which is the theoretical foundation for the resilience assessment and optimization research of CPPSs, are also presented. Lastly, the challenges and future research directions for resilience optimizing of CPPSs are discussed.

关键词： Cyber–Physical Power System     resilience assessment     resilience optimization     cascading failure modeling    

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Discussion on the System Optimization of the Energy Development Strategy and Plan

Da-di Zhou

《工程管理前沿（英文）》 2014年 第1卷 第2期   页码 147-152 doi: 10.15302/J-FEM-2014022

摘要： Energy is an important basis for economic and social development, and is a critical economic sector. Due to the complexity of the energy system, the interactive relationship with economic and social development, and the enormous investment involved, the optimization of the energy system is of great significance. We should make efforts to develop targets and specific approaches for the rational and optimal development of an energy system in order to avoid big losses due to systematic mistakes.

关键词： energy development strategy     planning system     system optimization    

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Distributed monitoring and diagnosis system for hydraulic system of construction machinery

Xiaohu CHEN, Wenfeng WU, Hangong WANG, Yongtao ZHOU,

《机械工程前沿（英文）》 2010年 第5卷 第1期   页码 106-110 doi: 10.1007/s11465-009-0089-7

摘要： This paper mainly presents a distributed monitoring and diagnosis system for the hydraulic system of construction machinery based on the controller area net (CAN) field bus. The hardware of the distributed condition monitoring and fault diagnosis system is designed. Its structure including the sensors, distributed data acquisition units, central signal processing unit, and CAN field bus is introduced. The software is also programmed. The general software design and its realization are studied in detail. The experiments and applications indicate that the distributed condition monitoring and fault diagnosis system can effectively realize its function of real-time online condition monitoring and fault diagnosis for the hydraulic system of construction machinery.

关键词： construction machinery     hydraulic system     distributed condition monitoring     controller area net (CAN) field bus     fault diagnosis    

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Theory and method of mechanism system design

Huijun ZOU, Qinghua LIANG, Qing ZHANG

《机械工程前沿（英文）》 2010年 第5卷 第4期   页码 399-411 doi: 10.1007/s11465-010-0116-8

摘要： Conceptual design is the most critical and creative phase of design. Recently, increasing attention has been directed to supporting conceptual-level computer aided creative design and its theories and methodologies. Specifically, for conceptual design of mechanical products, this paper presents a novel function solving model for mechanical product design and highlights the importance of systematic synthesis to achieve creative design. Then it builds a framework as a function-effect-process-action- mechanisms (FEPAM) mapping process, which enables creative design on the basis of conceiving different action schemes. After that, several key points are elaborated including 1) representing and decomposition methods of functions and motion behaviors; 2) action scheme representing method based on network plan techniques; and 3) variation and creation methods based on action scheme transformations.

关键词： mechanism system creative design     process model     function solving model     process action procedure     mechanisms knowledge base     principle of mechanism system composition    

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Dynamic contribution of variable-speed wind energy conversion system in system frequency regulation

Yajvender Pal VERMA, Ashwani KUMAR

《能源前沿（英文）》 2012年 第6卷 第2期   页码 184-192 doi: 10.1007/s11708-012-0185-y

摘要： Frequency regulation in a generation mix having large wind power penetration is a critical issue, as wind units isolate from the grid during disturbances with advanced power electronics controllers and reduce equivalent system inertia. Thus, it is important that wind turbines also contribute to system frequency control. This paper examines the dynamic contribution of doubly fed induction generator (DFIG)-based wind turbine in system frequency regulation. The modified inertial support scheme is proposed which helps the DFIG to provide the short term transient active power support to the grid during transients and arrests the fall in frequency. The frequency deviation is considered by the controller to provide the inertial control. An additional reference power output is used which helps the DFIG to release kinetic energy stored in rotating masses of the turbine. The optimal speed control parameters have been used for the DFIG to increases its participation in frequency control. The simulations carried out in a two-area interconnected power system demonstrate the contribution of the DFIG in load frequency control.

关键词： doubly fed induction generator (DFIG)     load frequency control     inertial control     wind energy conversion system (WECS)    

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Load frequency control in deregulated power system with wind integrated system using fuzzy controller

Yajvender Pal VERMA, Ashwani KUMAR

《能源前沿（英文）》 2013年 第7卷 第2期   页码 245-254 doi: 10.1007/s11708-012-0218-6

摘要： This paper presents the analysis of load frequency control (LFC) of a deregulated two-area hydro-thermal power system using fuzzy logic controller, with doubly fed induction generators (DFIGs) integrated into both the control areas. The deregulation of power sector has led to the formation of new companies for generation, transmission and distribution of power. The conventional two-area power system is modified to study the effects of the bilateral contracts of companies on the system dynamics. Deregulation creates highly competitive and distributed control environment, and the LFC becomes even more challenging when wind generators are also integrated into the system. The overall inertia of the system reduces, as the wind unit does not provide inertia and isolates from the grid during disturbances. The DFIGs integrated provide inertial support to the system through modified inertial control scheme, and arrests the initial fall in frequency after disturbance. The inertial control responds to frequency deviations, which takes out the kinetic energy of the wind turbine for improving the frequency response of the system. To enhance the participation of the doubly fed induction generator (DFIG) in the frequency control, optimal values of the speed control parameters of the DFIG-based wind turbine have been obtained using integral square error (ISE) technique. The dynamics of the system have been obtained for a small load perturbation, and for contract violation using fuzzy controller.

关键词： frequency regulation     fuzzy controller     de-regulated power system     doubly fed induction generator (DFIG)     bilateral contract    

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钱学森与系统工程

苗东升

《中国工程科学》 2002年 第4卷 第3期   页码 16-20

摘要：

考察了钱学森系统工程思想的孕育、发展过程，概述了他所提出的有中国特色系统工程理论的要点，分析了他如何走出系统工程、扩大视野。

关键词： 钱学森     系统思想     系统工程     系统科学    

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China’s hydropower energy system toward carbon neutrality

《工程管理前沿（英文）》   页码 677-682 doi: 10.1007/s42524-022-0196-2

摘要： Wind and solar powers will gradually become dominant energies toward carbon neutrality. Large-scale renewable energies, with strong stochasticity, high volatility, and unadjustable features, have great impacts on the safe operation of power system. Thus, an advanced hydropower energy system serving multiple energies is required to respond to volatility, with expanding role from a “stable energy supplier” to a “flexible efficiency regulator”. Future research and application can be considered from three aspects: 1) system expansion (e.g., the construction of large-scale hydropower/renewable energy bases in China, the construction of transnational hydropower energy internet, and the functional transformation of traditional hydropower reservoirs and generating units); 2) efficiency promotion (e.g., advanced intelligent forecasting, multi-objective operation, and risk management methods); and 3) supporting measures (e.g., market reform, benefit compensation and policy mechanism, technical standards, and laws and regulations).

关键词： hydropower system     carbon neutrality     artificial intelligence    

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标题 作者 时间 类型 操作

Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

期刊论文

P50 auditory sensory gating in first onset schizophrenics and normal healthy adults

WANG Hongxing, ZHANG Mingdao, CHEN Xingshi, LOU Feiying, LIANG Jianhua, CHEN Chong, SHI Tiantao, LU Qiulin

期刊论文

Behavioral methods for the functional assessment of hair cells in zebrafish

null

期刊论文

鸡尾酒会问题的技术回顾、当前进展及未来挑战

Yan-min QIAN, Chao WENG, Xuan-kai CHANG, Shuai WANG, Dong YU

期刊论文

AI2.0时代的类人与超人感知：研究综述与趋势展望

Yong-hong TIAN,Xi-lin CHEN,Hong-kai XIONG,Hong-liang LI,Li-rong DAI,Jing CHEN,Jun-liang XING,Jing CHEN,Xi-hong WU,Wei-min HU,Yu HU,Tie-jun HUANG,Wen GAO

期刊论文

System reliability and system resilience

期刊论文

工程 工程系统 工程系统论与工程科学体系

王连成

期刊论文

Cyber–Physical Power System (CPPS): A review on measures and optimization methods of system resilience

期刊论文

Discussion on the System Optimization of the Energy Development Strategy and Plan

Da-di Zhou

期刊论文

Distributed monitoring and diagnosis system for hydraulic system of construction machinery

Xiaohu CHEN, Wenfeng WU, Hangong WANG, Yongtao ZHOU,

期刊论文

Theory and method of mechanism system design

Huijun ZOU, Qinghua LIANG, Qing ZHANG

期刊论文

Dynamic contribution of variable-speed wind energy conversion system in system frequency regulation

Yajvender Pal VERMA, Ashwani KUMAR

期刊论文

Load frequency control in deregulated power system with wind integrated system using fuzzy controller

Yajvender Pal VERMA, Ashwani KUMAR

期刊论文

钱学森与系统工程

苗东升

期刊论文

China’s hydropower energy system toward carbon neutrality

期刊论文